Detalhe da pesquisa
1.
The novel capsazepine analog, CIDD-99, significantly inhibits oral squamous cell carcinoma in vivo through a TRPV1-independent induction of ER stress, mitochondrial dysfunction, and apoptosis.
J Oral Pathol Med
; 48(5): 389-399, 2019 May.
Artigo
Inglês
| MEDLINE | ID: mdl-30825343
2.
An engineered transforming growth factor ß (TGF-ß) monomer that functions as a dominant negative to block TGF-ß signaling.
J Biol Chem
; 292(17): 7173-7188, 2017 04 28.
Artigo
Inglês
| MEDLINE | ID: mdl-28228478
3.
Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells.
RNA Biol
; 15(11): 1420-1432, 2018.
Artigo
Inglês
| MEDLINE | ID: mdl-30362859
4.
Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease.
Biochim Biophys Acta
; 1862(5): 992-1007, 2016 05.
Artigo
Inglês
| MEDLINE | ID: mdl-26639036
5.
Corrigendum to "Synthesis and SAR of novel capsazepine analogs with significant anti-cancer effects in multiple cancer types" [Bioorg. Med. Chem. 27 (1) (2019) 208-215].
Bioorg Med Chem
; 27(11): 2280, 2019 Jun 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31014563
6.
Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease.
J Neurochem
; 124(6): 880-93, 2013 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-23121022
7.
Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy.
Nat Commun
; 14(1): 2367, 2023 04 25.
Artigo
Inglês
| MEDLINE | ID: mdl-37185259
8.
The role of MAP4K3 in lifespan regulation of Caenorhabditis elegans.
Biochem Biophys Res Commun
; 425(2): 413-8, 2012 Aug 24.
Artigo
Inglês
| MEDLINE | ID: mdl-22846570
9.
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Anal Biochem
; 421(2): 467-76, 2012 Feb 15.
Artigo
Inglês
| MEDLINE | ID: mdl-22178911
10.
mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging.
Aging Cell
; 19(1): e13057, 2020 01.
Artigo
Inglês
| MEDLINE | ID: mdl-31693798
11.
Rapamycin improves motor function, reduces 4-hydroxynonenal adducted protein in brain, and attenuates synaptic injury in a mouse model of synucleinopathy.
Pathobiol Aging Age Relat Dis
; 5: 28743, 2015.
Artigo
Inglês
| MEDLINE | ID: mdl-26306821
12.
Paradoxical effect of TrkA inhibition in Alzheimer's disease models.
J Alzheimers Dis
; 40(3): 605-617, 2014.
Artigo
Inglês
| MEDLINE | ID: mdl-24531152
13.
Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease.
J Cereb Blood Flow Metab
; 33(9): 1412-21, 2013 Sep.
Artigo
Inglês
| MEDLINE | ID: mdl-23801246
14.
Endogenously EGFP-Labeled Mouse Embryonic Stem Cells.
Aging Dis
; 2(1): 18-29, 2011 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-21874159
15.
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease.
PLoS One
; 5(4): e9979, 2010 Apr 01.
Artigo
Inglês
| MEDLINE | ID: mdl-20376313
16.
Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation.
J Biol Chem
; 280(26): 24680-9, 2005 Jul 01.
Artigo
Inglês
| MEDLINE | ID: mdl-15851471